An in-depth review of the hyper and hypopigmentation (vitiligo). The number one disorder worldwide for patients visiting a Dermatologist is hyperpigmentation. Vitiligo on the other hand is a disease which affects 0.5%-8% of the population. It is a very difficult condition to treat. In this course, we will explore Melanogenesis in detail as well as look into inhibitors and stimulators of Melanin synthesis as well as many other etiologies as to why one either produces too much pigment and why some people just don't make enough. The currently available treatments as well as new novel therapeutics will be explored.